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      ESR as a monitoring method of the interactions between TEMPO-functionalized magnetic nanoparticles and yeast cells

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          Abstract

          Potential application of magnetic nanoparticles as drug carriers in medical treatment requires prior determination of their effects on cells. In this work different spin labels and magnetic nanoparticles functionalized with spin labels as well as their interaction with yeast cells were investigated using electron spin resonance (ESR) method. ESR was demonstrated to be a suitable method for monitoring of magnetic core and attached spin labels. Particular emphasis was placed on characterization of endocytosis and redox processes running inside the cell, resulting in recombination of spin labels. Such data could only be obtained at reduced temperature of ESR measurements.

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          Controlled growth of monodisperse silica spheres in the micron size range

          Werner Stöber, Arthur Fink, Ernst Bohn (1968)
          Article 0 comments Cited 774 times – based on 0 reviews     Review now
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            Actin and Endocytosis in Budding Yeast

            Bruce L. Goode, Julian Eskin, Beverly Wendland (2015)
            Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is essential for bringing many substances into the cell and for membrane turnover. The mechanism driving clathrin-mediated endocytosis (CME) involves > 50 different protein components assembling at a single location on the plasma membrane in a temporally ordered and hierarchal pathway. These proteins perform precisely choreographed steps that promote receptor recognition and clustering, membrane remodeling, and force-generating actin-filament assembly and turnover to drive membrane invagination and vesicle scission. Many critical aspects of the CME mechanism are conserved from yeast to mammals and were first elucidated in yeast, demonstrating that it is a powerful system for studying endocytosis. In this review, we describe our current mechanistic understanding of each step in the process of yeast CME, and the essential roles played by actin polymerization at these sites, while providing a historical perspective of how the landscape has changed since the preceding version of the YeastBook was published 17 years ago (1997). Finally, we discuss the key unresolved issues and where future studies might be headed.
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              Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

              Yan Liu, Pengcheng Zhang, Feifei Li … (2018)
              Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.
              Article 0 comments Cited 96 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Bernadeta Dobosz: benia@amu.edu.pl
                Journal
                Journal ID (nlm-ta): Sci Rep
                Journal ID (iso-abbrev): Sci Rep
                Title: Scientific Reports
                Publisher: Nature Publishing Group UK (London )
                ISSN (Electronic): 2045-2322
                Publication date (Electronic): 10 December 2019
                Publication date PMC-release: 10 December 2019
                Publication date Collection: 2019
                Volume: 9
                Electronic Location Identifier: 18733
                Affiliations
                [1 ]ISNI 0000 0001 2097 3545, GRID grid.5633.3, Medical Physics Division, Faculty of Physics, , Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 2, ; 61-614 Poznań, Poland
                [2 ]ISNI 0000 0001 2097 3545, GRID grid.5633.3, Faculty of Chemistry, , Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614, ; Poznań, Poland
                Article
                Publisher ID: 55335
                DOI: 10.1038/s41598-019-55335-z
                PMC ID: 6904674
                PubMed ID: 31822759
                SO-VID: 47024b58-1775-48e8-803c-182a479ee4e3
                Copyright © © The Author(s) 2019
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 16 July 2019
                Date accepted : 20 November 2019
                Categories
                Subject: Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2019

                ScienceOpen disciplines: Uncategorized
                Keywords: biophysics,nanoscience and technology
                Data availability:
                ScienceOpen disciplines: Uncategorized
                Keywords: biophysics, nanoscience and technology

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