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      Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment.

      1 , ,
      The Lancet. Neurology
      Elsevier BV

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          Abstract

          Neuropathic pain develops as a result of lesions or disease affecting the somatosensory nervous system either in the periphery or centrally. Examples of neuropathic pain include painful polyneuropathy, postherpetic neuralgia, trigeminal neuralgia, and post-stroke pain. Clinically, neuropathic pain is characterised by spontaneous ongoing or shooting pain and evoked amplified pain responses after noxious or non-noxious stimuli. Methods such as questionnaires for screening and assessment focus on the presence and quality of neuropathic pain. Basic research is enabling the identification of different pathophysiological mechanisms, and clinical assessment of symptoms and signs can help to determine which mechanisms are involved in specific neuropathic pain disorders. Management of neuropathic pain requires an interdisciplinary approach, centred around pharmacological treatment. A better understanding of neuropathic pain and, in particular, of the translation of pathophysiological mechanisms into sensory signs will lead to a more effective and specific mechanism-based treatment approach.

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          Author and article information

          Journal
          Lancet Neurol
          The Lancet. Neurology
          Elsevier BV
          1474-4465
          1474-4422
          Aug 2010
          : 9
          : 8
          Affiliations
          [1 ] Sektion für Neurologische Schmerzforschung und-therapie, Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany. r.baron@neurologie.uni-kiel.de
          Article
          S1474-4422(10)70143-5
          10.1016/S1474-4422(10)70143-5
          20650402
          4713ae46-d163-44dc-af43-763226b589e5
          Copyright 2010 Elsevier Ltd. All rights reserved.
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