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      A REVIEW ON THE ANTIPARASITIC DRUG IVERMECTIN FOR VARIOUS VIRAL INFECTIONS AND POSSIBILITIES OF USING IT FOR NOVEL SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2: NEW HOPE TO TREAT CORONAVIRUS DISEASE-2019

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      Asian Journal of Pharmaceutical and Clinical Research
      Innovare Academic Sciences Pvt Ltd

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          Abstract

          The novel coronavirus infection has spread all over the world. With no specific drug or vaccine, the process of “drug repurposing” becomes a feasible solution. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has 80% sequence similarity with the SARS-CoV, the nuclear import inhibitor “Ivermectin” (IVM) has recently been studied as a possible treatment option for coronavirus disease-2019 (COVID-19). The article aims to provide a review on structure and immunogenicity of SARS-CoV-2, indications of IVM for viral diseases, its possible mechanism on COVID-19 with a brief discussion on IVM structure, pharmacokinetics, adverse drug reactions, drug interactions, and contraindications. Further, we made possible comparisons of IVM with solidarity trial drugs and analyzed its major advantages, limitations and gave necessary recommendations for its use in future in vivo studies in the treatment of COVID-19.

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          Author and article information

          Journal
          Asian Journal of Pharmaceutical and Clinical Research
          Asian J Pharm Clin Res
          Innovare Academic Sciences Pvt Ltd
          2455-3891
          0974-2441
          August 07 2020
          June 20 2020
          : 21-27
          Article
          10.22159/ajpcr.2020.v13i8.38357
          471833d3-9006-452b-9486-240b7204fa4d
          © 2020

          http://creativecommons.org/licenses/by/4.0

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