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Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma.
D B Price
1 ,
D Hernandez ,
P Magyar ,
J Fiterman ,
K M Beeh ,
I G James ,
S Konstantopoulos ,
R Rojas ,
J A van Noord ,
M Pons ,
L Gilles ,
J A Leff
Mar 2003
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Abstract
Inhaled corticosteroids (ICS) affect many inflammatory pathways in asthma but have little impact on cysteinyl leukotrienes. This may partly explain persistent airway inflammation during chronic ICS treatment and failure to achieve adequate asthma control in some patients. This double blind, randomised, parallel group, non-inferiority, multicentre 16 week study compared the clinical benefits of adding montelukast to budesonide with doubling the budesonide dose in adults with asthma.