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      From Creation to Consolidation: A Novel Framework for Memory Processing

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      Journal: PLoS Biology
      Publisher: Public Library of Science

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          Abstract

          Long after playing squash, your brain continues to process the events that occurred during the game, thereby improving your game, and more generally, enhancing adaptive behavior. Understanding these mysterious processes may require novel theories.

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          Memory--a century of consolidation.

          J McGaugh (2000)
          The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.
          Article 0 comments Cited 521 times – based on 0 reviews     Review now
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            Breakdown of cortical effective connectivity during sleep.

            Marcello Massimini, Fabio Ferrarelli, Reto Huber … (2005)
            When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response (approximately 15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity.
            Article 0 comments Cited 426 times – based on 0 reviews     Review now
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              Synaptic plasticity, memory and the hippocampus: a neural network approach to causality.

              Guilherme Neves, Sam F Cooke, Tim Bliss (2008)
              Two facts about the hippocampus have been common currency among neuroscientists for several decades. First, lesions of the hippocampus in humans prevent the acquisition of new episodic memories; second, activity-dependent synaptic plasticity is a prominent feature of hippocampal synapses. Given this background, the hypothesis that hippocampus-dependent memory is mediated, at least in part, by hippocampal synaptic plasticity has seemed as cogent in theory as it has been difficult to prove in practice. Here we argue that the recent development of transgenic molecular devices will encourage a shift from mechanistic investigations of synaptic plasticity in single neurons towards an analysis of how networks of neurons encode and represent memory, and we suggest ways in which this might be achieved. In the process, the hypothesis that synaptic plasticity is necessary and sufficient for information storage in the brain may finally be validated.
              Article 0 comments Cited 345 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): PLoS Biol
                Journal ID (publisher-id): pbio
                Journal ID (publisher-id): plbi
                Journal ID (pmc): plosbiol
                Title: PLoS Biology
                Publisher: Public Library of Science (San Francisco, USA )
                ISSN (Print): 1544-9173
                ISSN (Electronic): 1545-7885
                Publication date (Print): January 2009
                Publication date (Electronic): 27 January 2009
                Volume: 7
                Issue: 1
                Electronic Location Identifier: e19
                Article
                Publisher ID: 08-PLBI-E-1623R4
                DOI: 10.1371/journal.pbio.1000019
                PMC ID: 2631067
                PubMed ID: 19175290
                SO-VID: 47427188-5ca4-4d85-9be7-9e6688eb8208
                Copyright © Copyright: © 2009 Edwin M. Robertson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                Page count
                Pages: 9
                Categories
                Subject: Essay
                Subject: Neuroscience
                Custom metadata
                citation Robertson EM (2009) From creation to consolidation: A novel framework for memory processing. PLoS Biol 7(1): e1000019. doi: 10.1371/journal.pbio.1000019

                ScienceOpen disciplines: Life sciences
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                ScienceOpen disciplines: Life sciences

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