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      The Effect of Maternal Hypothyroidism on Maternal and Fetal Tissue Glucose-1- 14C Incorporation in Rats


      Hormone Research in Paediatrics

      S. Karger AG

      Hypothyroidism, Pregnancy, Carbohydrate metabolism

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          These experiments were conducted to help elucidate the mechanism for the impaired fetal development occurring during maternal hypothyroidism. The disposition of glucose was measured using glucose-1-<sup>14</sup>C. Maternal hypothyroidism depressed glucose utilization in the maternal-fetal system. Maternal net glycogen synthesis from the labeled glucose was impaired. However, while the fetal glycogen storage system may be capable of at least relatively normal glycogen synthesis, abnormally low levels of glycogen were measured. If, as the data suggest, enzymatic deficiencies do not exist, the low liver glycogen might be a result of the inability of the maternal-placental system to provide adequate substrate to the fetus.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 6
          : 4
          : 236-246
          School of Biology, Georgia Institute of Technology, Atlanta, Ga., and Department of Physiology, Medical College of Georgia, Augusta, Ga.
          178697 Horm Res 1975;6:236–246
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 11


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