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      Effects of Hypoxia on Vasopressin Concentrations in Cerebrospinal Fluid and Plasma of Sheep

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          The relationship between concentrations of vasopressin in plasma and cerebrospinal fluid (CSF) was examined under basal and hypoxic conditions in unanesthetized and unrestrained adult female sheep. Under basal conditions mean (± SE) concentration of vasopressin (4.1 ± 0.3 pg/ml) in CSF was significantly (p< 0.001) higher than the concentration in arterial plasma (2.4 + 0.2 pg/ml). There was a significant positive correlation between CSF and plasma vasopressin concentrations (r = 0.66, p < 0.01). The introduction of severe hypoxia by exposure of the sheep to an inspired gas mixture of 5% O<sub>2</sub> in N<sub>2</sub>, a known stimulus to systemic release of vasopressin, was associated with an increase in the concentration of vasopressin in plasma to 339 ± 65 pg/ml and CSF to 19 ± 3.9 pg/ml. This increase of vasopressin in CSF was delayed in time with respect to the increases in the plasma and of a lesser magnitude. With moderate hypoxia (10% O<sub>2</sub> in N<sub>2</sub> exposure) no increase in CSF or plasma vasopressin concentration was observed, suggesting a threshold response. Intravenous infusion of vasopressin to achieve plasma values comparable to those seen with hypoxia was not accompanied by a significant increase in CSF vasopressin concentration. Thus, severe hypoxia is a potent stimulus for release of vasopressin into both CSF and plasma. Furthermore, data suggest that vasopressin may be released into CSF via a separate route from that released into plasma.

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          Author and article information

          S. Karger AG
          28 March 2008
          : 38
          : 6
          : 453-460
          Division of Perinatal Medicine, Departments of Pediatrics, Anesthesiology, and Obstetrics and Gynecology, College of Physician and Surgeons, Columbia University, New York, N.Y., USA
          123933 Neuroendocrinology 1984;38:453–460
          © 1984 S. Karger AG, Basel

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          Pages: 8
          Original Paper


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