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      • Record: found
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      Sex modifies the APOE-related risk of developing Alzheimer disease.

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      Publication date:
      Journal: Annals of Neurology
      Publisher: Wiley

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          Abstract

          The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD). Case-control studies suggest the APOE4 link to AD is stronger in women. We examined the APOE4-by-sex interaction in conversion risk (from healthy aging to mild cognitive impairment (MCI)/AD or from MCI to AD) and cerebrospinal fluid (CSF) biomarker levels.

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          Journal
          PubMed ID:: 24623176
          PMC ID:: 4117990
          DOI:: 10.1002/ana.24135

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