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      Facile synthesis of hollow mesoporous nickel sulfide nanoparticles for highly efficient combinatorial photothermal–chemotherapy of cancer

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          Abstract

          Novel synthesis of hollow mesoporous (hm)-NiS NPs and the derivative of NiPPD NPs for highly efficient tumor combination therapy.

          Abstract

          Traditional techniques for the synthesis of nickel sulfide (NiS) nanoparticles (NPs) always present drawbacks of morphological irregularity, non-porous structure and poor long-term stability, which are extremely unfavorable for establishing effective therapeutic agents. Here, a category of hollow mesoporous NiS (hm-NiS) NPs with uniform spherical structure and good aqueous dispersity were innovatively developed based on a modified solvothermal reaction technique. Upon the successful synthesis of hm-NiS NPs, dopamine was seeded and in situ polymerized into polydopamine (PDA) on the NP surface, followed by functionalization with thiol-polyethylene glycol (SH-PEG) and encapsulation of the chemotherapeutic drug, doxorubicin (DOX), to form hm-NiS@PDA/PEG/DOX (NiPPD) NPs. The resultant NiPPD NPs exhibited a decent photothermal response and stability, attributed to the optical absorption of the hm-NiS nanocore and PDA layer in the near-infrared (NIR) region. Furthermore, stimulus-responsive drug release was achieved under both acidic pH conditions and NIR laser irradiation, owing to the protonation of –NH 2 groups in the DOX molecules and local thermal shock, respectively. Lastly, a strong combinatorial photothermal–chemotherapeutic effect was demonstrated for tumor suppression with minimal systemic toxicity in vivo. Collectively, this state-of-the-art paradigm may provide useful insights to deepen the application of hm-NiS NPs for disease management and precision medicine.

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          Author and article information

          Contributors
          Journal
          JMCBDV
          Journal of Materials Chemistry B
          J. Mater. Chem. B
          Royal Society of Chemistry (RSC)
          2050-750X
          2050-7518
          September 2 2020
          2020
          : 8
          : 34
          : 7766-7776
          Affiliations
          [1 ]State Key Laboratory of Silkworm Genome Biology
          [2 ]School of Materials and Energy
          [3 ]Southwest University
          [4 ]Chongqing 400715
          [5 ]China
          [6 ]College of Biotechnology
          [7 ]Chongqing 400716
          Article
          10.1039/D0TB01448F
          47884265-5871-45e0-bd96-b66a93c2ca1a
          © 2020

          http://rsc.li/journals-terms-of-use

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