Blog
About

15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      CD95's deadly mission in the immune system.

      Nature

      cytology, Thymus Gland, immunology, T-Lymphocytes, Signal Transduction, Membrane Glycoproteins, Intracellular Signaling Peptides and Proteins, Humans, Fas Ligand Protein, physiology, Carrier Proteins, CASP8 and FADD-Like Apoptosis Regulating Protein, B-Lymphocytes, Apoptosis, Antigens, CD95, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Apoptosis in the immune system is a fundamental process regulating lymphocyte maturation, receptor repertoire selection and homeostasis. Thus, death by apoptosis is as essential for the function of lymphocytes as growth and differentiation. This article focuses on death receptor-associated apoptosis and the role of CD95 (Apo-1/Fas)-mediated signalling in T-cell and B-cell development and during the course of an immune response. Gaining an insight into these processes improves our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and opens new approaches to rational treatment strategies.

          Related collections

          Author and article information

          Journal
          10.1038/35037728
          11048730

          Comments

          Comment on this article