15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Molecular Mechanisms of Myocardial Remodeling

      1
      Physiological Reviews
      American Physiological Society

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references383

          • Record: found
          • Abstract: not found
          • Article: not found

          Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.

              To identify the role of the myocardial beta-adrenergic pathway in congestive heart failure, we examined beta-adrenergic-receptor density, adenylate cyclase and creatine kinase activities, muscle contraction in vitro, and myocardial contractile protein levels in the left ventricles of failing and normally functioning hearts from cardiac-transplant recipients or prospective donors. Eleven failing left ventricles had a 50 to 56 per cent reduction in beta-receptor density, a 45 per cent reduction in maximal isoproterenol-mediated adenylate cyclase stimulation, and a 54 to 73 per cent reduction in maximal isoproterenol-stimulated muscle contraction, as compared with six normally functioning ventricles (P less than 0.05 for each comparison). In contrast, cytoplasmic creatine kinase activity, adenylate cyclase activities stimulated by fluoride ion and by histamine, histamine-stimulated muscle contraction, and levels of contractile protein were not different in the two groups (P less than 0.05). We conclude that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction. Regulation of beta-adrenergic receptors may be an important variable in cardiac failure.
                Bookmark

                Author and article information

                Journal
                Physiological Reviews
                Physiological Reviews
                American Physiological Society
                0031-9333
                1522-1210
                January 1999
                January 1999
                : 79
                : 1
                : 215-262
                Affiliations
                [1 ]Institut National de la Santé et de la Recherche Médicale U. 127, Hôpital Lariboisière, Paris, France
                Article
                10.1152/physrev.1999.79.1.215
                47c00781-0b8f-4bd9-88cf-77d27ec76c01
                © 1999

                Comments

                Comment on this article