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Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary
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Abstract
Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation
in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone.
Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis.
Inhibition of cyclic AMP accumulation is specific for melatonin, since its analogs
N-acetylserotonin and 5-methoxytryptamine are 1000 times less potent. Cyclic nucleotides
may thus serve as second messengers transducing the effect of melatonin on cellular
level.