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      gem-Difluoroallylation of Aryl Diazoesters via Catalyst-Free, Blue-Light-Mediated Formal Doyle–Kirmse Reaction

      1 , 1 , 1 , 1 , 1 , 1
      Organic Letters
      American Chemical Society (ACS)

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          Abstract

          <p class="first" id="d11640794e93">A first example of low-energy blue-light-mediated formal Doyle-Kirmse reaction for gem-difluoroallylation of aryl diazoesters has been developed. A variety of highly functionalized gem-difluoroallyl containing esters bearing transformable sulfur and bromine groups were efficiently assembled with broad substrate scope under mild, catalyst-free, and additive-free conditions. The reaction represents a practical and environmentally friendly approach for C-CF2 bond formation based on rearrangement strategy, which will find potential applications among drug discovery and development. </p>

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          Author and article information

          Journal
          Organic Letters
          Org. Lett.
          American Chemical Society (ACS)
          1523-7060
          1523-7052
          March 29 2019
          March 29 2019
          Affiliations
          [1 ]Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China
          Article
          10.1021/acs.orglett.9b00647
          30924672
          47cfd4c8-772a-4526-bf5b-6ab5765ddf54
          © 2019
          History

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