Breast cancer, endometrial cancer, and cardiovascular events in participants who used vaginal estrogen in the Womenʼs Health Initiative Observational Study

Crandall, Carolyn J; Hovey, Kathleen M.; Andrews, Christopher A.; Chlebowski, Rowan T; Stefanick, Marcia L; Lane, Dorothy S.; Shifren, Jan L; Chen, Chu C; Kaunitz, Andrew M; Cauley, Jane A.; Manson, JoAnn E.

doi:10.1097/GME.0000000000000956

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Breast cancer, endometrial cancer, and cardiovascular events in participants who used vaginal estrogen in the Womenʼs Health Initiative Observational Study :

Author(s): Carolyn J. Crandall , Kathleen M. Hovey , Christopher A. Andrews , Rowan T. Chlebowski , Marcia L. Stefanick , Dorothy S. Lane , Jan Shifren , Chu Chen , Andrew M. Kaunitz , Jane A. Cauley , JoAnn E. Manson

Publication date (Print): August 2017

Journal: Menopause

Publisher: Ovid Technologies (Wolters Kluwer Health)

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Abstract

To determine the association between use of vaginal estrogen and risk of a global index event (GIE), defined as time to first occurrence of coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal cancer, endometrial cancer, or death from any cause.