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      Coronary collaterals during single‐vessel coronary angioplasty: Effects of nitroglycerin

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          Abstract

          Background: Although the protective role of collaterals in coronary artery disease (CAD) is well known, the influence of drugs on collateral function remains controversial.

          Hypothesis: We aimed to investigate prospectively the prevalence of spontaneously visible and recruitable coronary collaterals in consecutive patients with single‐vessel CAD and the effect of systemic administration of nitroglycerin on these types of collaterals during percutaneous transluminal coronary angioplasty (PTCA).

          Methods: Ipsi‐ and contralateral coronary artery contrast injections were performed before and during PTCA. Simultaneously with balloon occlusion, we measured coronary artery occlusion pressure via the balloon catheter. All measurements were repeated after administration of 0.5 mg of nitroglycerin intravenously.

          Results: Of 101 consecutive patients, 24% had spontaneously visible and 30% had recruitable collaterals. Contra‐lateral collaterals were five times more frequent than ipsilateral collaterals. Presence of collaterals was highly associated with the degree of coronary stenosis. Coronary occlusion pressure was higher in patients with than in those without collaterals. Collaterals prevented pain and ischemia during PTCA, and in this respect spontaneously visible collaterals were more effective than recruitable collaterals. There was no effect of systemic administration of nitroglycerin on appearance or occlusion pressure of coronary collaterals.

          Conclusion: Coronary collaterals were found in more than half of patients with single‐vessel CAD, as the prevalence of recruitable collaterals was slightly higher than that of spontaneously visible collaterals. Nitroglycerin did neither recruit nor augment coronary collaterals.

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          Author and article information

          Journal
          Clin Cardiol
          Clin Cardiol
          10.1002/(ISSN)1932-8737
          CLC
          Clinical Cardiology
          Wiley Periodicals, Inc. (New York )
          0160-9289
          1932-8737
          05 December 2006
          July 2002
          : 25
          : 7 ( doiID: 10.1002/clc.v25:7 )
          : 340-344
          Affiliations
          [ 1 ]Department of Cardiology, Skejby University Hospital, Aarhus, Denmark
          [ 2 ]Cardiothoracic Directorate, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, U.K.
          Author notes
          [* ]Cardiothoracic Directorate Hammersmith Hospital London W12 ONN, U.K.
          Article
          PMC6654386 PMC6654386 6654386 CLC4950250707
          10.1002/clc.4950250707
          6654386
          12109868
          Copyright © 2002 Wiley Periodicals, Inc.
          Page count
          Figures: 4, Tables: 2, References: 14, Pages: 5
          Funding
          Funded by: The Danish Heart Foundation
          Categories
          Clinical Investigation
          Clinical Investigations
          Custom metadata
          2.0
          July 2002
          Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.2.1 mode:remove_FC converted:09.05.2019

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