Genetically Determined Schizophrenia is not associated with Impaired Glucose Homeostasis

Abstract

Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis, and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Mendelian randomization analysis was well-powered, no causal relationship was observed among schizophrenia, T2D, and traits related to glucose impaired homeostasis. Similarly, we did not observe any global genetic overlap among these traits. These findings indicate that there is no causal relationships or shared mechanisms between schizophrenia and impaired glucose homeostasis.