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      GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.

      Nature reviews. Molecular cell biology

      chemistry, rho GTP-Binding Proteins, ras-GRF1, Signal Transduction, Protein Structure, Tertiary, Protein Binding, Phylogeny, metabolism, Neurons, Models, Molecular, Models, Biological, Mice, Lipid Bilayers, Humans, Guanine Nucleotide Exchange Factors, Animals, Allosteric Site

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          Abstract

          Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.

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          Journal
          15688002
          10.1038/nrm1587

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