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      IgA Nephropathy: Association of a History of Macroscopic Hematuria Episodes with Increased Production of Polymeric IgA

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          Abstract

          From the clinical point of view patients with IgA nephropathy present two main symptoms. Some patients have episodes of macroscopic hematuria, either isolated or recurrent, while others present only asymptomatic urinary abnormalities. Although these differences could be due to age-related, geographical or other unknown reasons, in this paper we studied whether patients with these two clinical manifestations differ in some IgA immunological aspects, described occasionally as abnormal in this disease. The following results were obtained: patients having a history of macroscopic hematuria episodes (n = 29) had a significant increase in the percentage of blood polymeric-IgA-producing cells (68 ± 12%) and in the T cells with IgA Fc-receptors (Tα cells; 14.5 ± 3%) in relation to those having only asymptomatic urinary abnormalities (n = 13; 48 ± 11 and 11.8 ± 3%, respectively). However, there was no difference in the two groups of patients in relation to the serum IgA levels, percentage of IgA-bearing cells, in vitro synthesis of IgA, T-cell subpopulation and generation of Con A-Ig A suppressor cells. Since these patients did not differ in the age of the apparent onset of the disease, in age at the moment of the study or in the activity of the disease determined by hematuria, our results afford an immunological support suggesting the existence of two subgroups of patients with IgA nephropathy.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 45
          : 2
          : 98-103
          Affiliations
          Servicio de Nefrología, Fundación Jiménez Díaz, Madrid, Spain
          Article
          184087 Nephron 1987;45:98–103
          10.1159/000184087
          2951607
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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