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      Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.

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          Abstract

          Youths with a family history of alcohol and other drug use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH-), and this increased risk may be related to impaired maturation of forebrain circuitry. FH+ individuals have shown altered forebrain activity at rest and while performing cognitive tasks. However, it is not fully understood how forebrain activity is altered in FH+ individuals, and ultimately how these alterations may contribute to substance use disorder risk.

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          Author and article information

          Journal
          Alcohol. Clin. Exp. Res.
          Alcoholism, clinical and experimental research
          1530-0277
          0145-6008
          Dec 2014
          : 38
          : 12
          Affiliations
          [1 ] Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
          Article
          NIHMS629529
          10.1111/acer.12571
          25406902
          Copyright © 2014 by the Research Society on Alcoholism.

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