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      Physics and applications of microfluidics in biology.

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          Abstract

          Fluid flow at the microscale exhibits unique phenomena that can be leveraged to fabricate devices and components capable of performing functions useful for biological studies. The physics of importance to microfluidics are reviewed. Common methods of fabricating microfluidic devices and systems are described. Components, including valves, mixers, and pumps, capable of controlling fluid flow by utilizing the physics of the microscale are presented. Techniques for sensing flow characteristics are described and examples of devices and systems that perform bioanalysis are presented. The focus of this review is microscale phenomena and the use of the physics of the scale to create devices and systems that provide functionality useful to the life sciences.

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          Author and article information

          Journal
          Annu Rev Biomed Eng
          Annual review of biomedical engineering
          Annual Reviews
          1523-9829
          1523-9829
          2002
          : 4
          Affiliations
          [1 ] Department of Biomedical Engineering, University of Wisconsin, Madison 53706, USA. dbeebe@engr.wisc.edu
          Article
          112601.125916
          10.1146/annurev.bioeng.4.112601.125916
          12117759
          481bd758-9f20-4ec1-9dfa-35494a92fefe
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