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      Diagnosis and Management of the Antiphospholipid Syndrome

      1 , 1

      New England Journal of Medicine

      New England Journal of Medicine (NEJM/MMS)

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          The pathogenesis of the antiphospholipid syndrome.

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            Guidelines on the investigation and management of antiphospholipid syndrome.

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              Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.

              Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neutrophils has not been extensively studied. Neutrophil extracellular traps (NETs) have recently been recognized as an important activator of the coagulation cascade, as well as an integral component of arterial and venous thrombi. This study was undertaken to determine whether aPL activate neutrophils to release NETs, thereby predisposing to the arterial and venous thrombosis inherent in the antiphospholipid syndrome (APS).
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                Author and article information

                Journal
                New England Journal of Medicine
                N Engl J Med
                New England Journal of Medicine (NEJM/MMS)
                0028-4793
                1533-4406
                May 24 2018
                May 24 2018
                : 378
                : 21
                : 2010-2021
                Affiliations
                [1 ]From the University of Washington School of Medicine, Seattle (D.G.); and the Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York (D.E.).
                Article
                10.1056/NEJMra1705454
                29791828
                © 2018
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