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      Regulators of the cytoplasmic dynein motor.

      Nature reviews. Molecular cell biology

      Adaptor Proteins, Signal Transducing, metabolism, Microtubule-Associated Proteins, Humans, chemistry, Dyneins, Cytoplasm, Animals

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          Abstract

          Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport activities as the many different types of kinesin. How is dynein coupled to its wide range of cargos and how is it spatially and temporally regulated? The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NUDE) and NUDE-like, Bicaudal D, Rod-ZW10-Zwilch and Spindly, that regulate dynein function and localization.

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          Author and article information

          Journal
          19935668
          10.1038/nrm2804
          3394690

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