Dramatic Expansion of HSCs: New Possibilities for HSC Transplants?

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Abstract

The identification of mechanisms that regulate stem cell renewal has led to the development of innovative approaches to expand hematopoietic stem cells ex vivo. One approach reported by Wagner et al. (2016) in this issue of Cell Stem Cell has demonstrated dramatic expansion of umbilical cord blood stem cells that promote rapid engraftment while maintaining capacity for long-term hematopoiesis.

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Journal

Journal ID (iso-abbrev): Cell Stem Cell

Title: Cell stem cell

Publisher: Elsevier BV

ISSN (Electronic): 1875-9777

ISSN (Print): 1875-9777

Publication date (Electronic): Jan 07 2016

Volume: 18

Issue: 1

Affiliations

[1 ] Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

[2 ] Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: jerome_ritz@dfci.harvard.edu.

Article

Publisher Item ID: S1934-5909(15)00556-1

DOI: 10.1016/j.stem.2015.12.011

PubMed ID: 26748750

SO-VID: 4846dcff-67d9-418c-b332-92a1a33f5861

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