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      Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole.

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          Abstract

          Aripiprazole is an atypical antipsychotic drug which is metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). The aim of the present study was to investigate the impact of the CYP2D6 genotype on serum concentrations of aripiprazole (ARI) and to determine the sum of ARI and the active metabolite dehydroaripiprazole (DARI) in psychiatric patients.

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          Author and article information

          Journal
          Eur. J. Clin. Pharmacol.
          European journal of clinical pharmacology
          0031-6970
          0031-6970
          Dec 2007
          : 63
          : 12
          Affiliations
          [1 ] Department of Psychopharmacology, Diakonhjemmet Hospital, PO Box 85, Vinderen, 0319 Oslo, Norway. Magnhild.hendset@diakonsyk.no
          Article
          10.1007/s00228-007-0373-6
          17828532

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