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      Standstill of Nailfold Capillary Blood Flow during Cooling in Scleroderma and Raynaud’s Syndrome

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          Abstract

          Capillary blood flow in nailfold capillaries, observed continuously by capillary microscopy during standardized cold exposure (16 °C) has been compared in 15 patients with scleroderma (SD), 6 patients with Raynaud’s syndrome (RS) without known organic pathology, and 9 normal controls. Capillary microscopy affords direct observation of capillary blood flow and allows one to determine if standstill of capillary circulation occurs (as defined by the movement of the red blood cell column), a state impossible to differentiate from near zero flow by conventional methods. Complete standstill of capillary blood flow occurred in 10 of 15 patients with SD and in 1 of 6 patients with RS. Intermittent standstill was observed in 5 of 15 SD and in 4 of 6 RS patients. In all normal subjects and in 1 of 6 patients with RS the capillary blood flow continued throughout the cooling period. Thus all 15 patients with SD and 5 of 6 patients with RS could be distinguished from control subjects by the development of capillary standstill on cooling. It is concluded that capillary microscopy can separate SD and RS patients from control subjects during cold exposure and may be useful in early diagnosis and prognosis of rheumatic syndromes and in the evaluation of therapy designed to improve the nutritional capillary blood flow of the skin. Whereas the complete standstill of capillary blood flow appears to be definitely associated with pathology, the intermittent standstill pattern as defined in this study may be an exaggerated form of flow fluctuation also seen in normal subjects. A larger number of subjects will have to be studied to determine whether patients with RS of the vasospastic type without connective tissue disease can be distinguished from normal subjects with low finger blood flow rates in cold conditions.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1976
          1976
          18 September 2008
          : 13
          : 6
          : 338-349
          Affiliations
          Departments of Medicine and Rehabilitation Medicine, College of Physicians and Surgeons, Columbia University, New York, N.Y. and Essex County Hospital Center, Cedar Grove, NJ.
          Article
          158104 Blood Vessels 1976;13:338–349
          10.1159/000158104
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 12
          Categories
          Research Paper

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