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      Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research.

      Molecular Microbiology
      Bacillus subtilis, metabolism, Cell Wall, L Forms, Protoplasts

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          Abstract

          Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is challenging. Domínguez-Cuevas et al. (2011) report a method to rapidly, quantitatively and reproducibly generate populations of L-forms in Bacillus subtilis. Importantly, the methodology may be applicable to other bacteria heralding a new era of L-form research. Moreover, the genetic requirements of this method provide insights into how Lipid II synthesis and autolysin expression/activity are normally balanced and the central role of the WalRK two-component system in this process. © 2011 Blackwell Publishing Ltd.

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          Author and article information

          Journal
          22126136
          10.1111/j.1365-2958.2011.07922.x

          Chemistry
          Bacillus subtilis,metabolism,Cell Wall,L Forms,Protoplasts
          Chemistry
          Bacillus subtilis, metabolism, Cell Wall, L Forms, Protoplasts

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