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      Mathematical modeling and experimental testing of three bioreactor configurations based on windkessel models

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      Heart International

      PAGEPress Publications

      bioreactor, design, heart valve, tissue engineering, windkessel models.

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          Abstract

          This paper presents an experimental study of three bioreactor configurations. The bioreactor is intended to be used for the development of tissue-engineered heart valve substitutes. Therefore it must be able to reproduce physiological flow and pressure waveforms accurately. A detailed analysis of three bioreactor arrangements is presented using mathematical models based on the windkessel (WK) approach. First, a review of the many applications of this approach in medical studies enhances its fundamental nature and its usefulness. Then the models are developed with reference to the actual components of the bioreactor. This study emphasizes different conflicting issues arising in the design process of a bioreactor for biomedical purposes, where an optimization process is essential to reach a compromise satisfying all conditions. Two important aspects are the need for a simple system providing ease of use and long-term sterility, opposed to the need for an advanced (thus more complex) architecture capable of a more accurate reproduction of the physiological environment. Three classic WK architectures are analyzed, and experimental results enhance the advantages and limitations of each one.

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          Most cited references 34

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          Noninvasive pulse wave analysis for the early detection of vascular disease.

          A noninvasive technique has been developed and validated for calculating capacitive and oscillatory systemic arterial compliance with the use of pulse wave analysis and a modified Windkessel model. Application of the technique to subjects with hypertension, postmenopausal women with symptomatic coronary artery disease, and appropriate control subjects has confirmed a reduction of oscillatory compliance in the disease states and an increase in capacitive and oscillatory compliances in response to vasodilator drugs. This method should be useful in screening subjects for early evidence of vascular disease and in monitoring the response to therapy.
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            An artificial arterial system for pumping hearts.

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              Vascular tissue engineering.

               D Seliktar,  R M Nerem (2000)
              The development of a tissue-engineered blood vessel substitute has motivated much of the research in the area of cardiovascular tissue engineering over the past 20 years. Several methodologies have emerged for constructing blood vessel replacements with biological functionality. These include cell-seeded collagen gels, cell-seeded biodegradable synthetic polymer scaffolds, cell self-assembly, and acellular techniques. This review details the most recent developments, with a focus on core technologies and construct development. Specific examples are discussed to illustrate both the benefits and shortcomings of each methodology, as well as to underline common themes. Finally, a brief perspective on challenges for the future is presented.
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                Author and article information

                Journal
                Heart Int
                HI
                HI
                Heart International
                PAGEPress Publications (Pavia, Italy )
                1826-1868
                2036-2579
                23 June 2010
                23 June 2010
                : 5
                : 1
                Affiliations
                Department of Mechanical Engineering, Laval University, Québec, QC, Canada
                Author notes
                Correspondence: Jean Ruel, 1026 avenue de la Médecine, Pavillon Pouliot, office 1361, Québec, PQ, GIV 0A6, Canada. E-mail: jruel@ 123456gmc.ulaval.ca
                Article
                hi.2010.e1
                10.4081/hi.2010.e1
                3184706
                21977286
                ©Copyright J. Ruel et al., 2010

                This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0).

                Licensee PAGEPress, Italy

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                Categories
                Article

                Cardiovascular Medicine

                tissue engineering, windkessel models., heart valve, design, bioreactor

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