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      Serum Growth Hormone Measurements in Clinical Practice: An Audit of Performance from the UK National External Quality Assessment Scheme

      , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Audit, Growth hormone, Standardization, Immunoassay, Quality assessment

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          Abstract

          The replacement of growth hormone (GH) radioimmunoassays with a variety of more specific immunometric methods in diagnostic service laboratories has led to a worsening of between-laboratory agreement, reflecting differences in method bias. Incorrect calibration and differences in specificity are important causes of method bias, but the impact of this on interpretation is not clear. In order to maximize the diagnostic reliability of GH testing for small stature, manufacturers should carefully calibrate their methods against the appropriate GH International Standard, and should use antibodies of broadly agreed specificity. Laboratories performing GH tests should participate in a reliable External Quality Assessment (EQA) scheme and guidelines for investigation that incorporate normal GH responses should be agreed.

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          Most cited references 1

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          Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited

           R Rosenfeld (1995)
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            Author and article information

            Journal
            HRE
            Horm Res Paediatr
            10.1159/issn.1663-2818
            Hormone Research in Paediatrics
            S. Karger AG
            978-3-8055-6898-2
            978-3-318-00450-2
            1663-2818
            1663-2826
            1999
            June 1999
            17 November 2004
            : 51
            : Suppl 1
            : 13-19
            Affiliations
            UK NEQAS for Peptide Hormones, Department of Clinical Biochemistry, The Royal Infirmary NHS Trust, Edinburgh, UK
            Article
            53130 Horm Res 1999;51(suppl 1):13–19
            10.1159/000053130
            10393486
            © 2004 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 7, Tables: 2, References: 14, Pages: 7
            Categories
            Standardization of Growth Hormone Measurement

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