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      Fructose-1,6-Diphosphate: Potential Protection in Cyclosporine-lnduced Renal Impairment

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          There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine if FDP also protects against cyclosporine (CsA)-induced nephrotoxicity, two groups of adult male Wistar rats were studied for whole kidney clearance rates. After two initial control periods, group 1 received only CsA (CsA, n = 8). Group 2 received FDP 350 mg/kg, followed by CsA 50 mg/kg (FDP-CsA, n = 6). In both groups, after a 30-min equilibration period, two additional clearance rates were measured (Postl and Post2). A significant reduction in clearance rates was observed after drug infusion in both groups (approximately 58 and 64% in CsA and FDP-CsA groups, respectively, p < 0.05) with a recovery to control values in the Post2 period in the FDP-CsA group. These data suggest a protective effect of FDP on CsA-induced renal impairment.

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          Author and article information

          S. Karger AG
          18 December 2008
          : 72
          : 1
          : 67-71
          Nephrology Divisions, aUniversidade Federal do Rio de Janeiro, bEscola Paulista de Medicina, São Paulo, and cUniversidade Federal do Rio Grande do Sul, Pôrto Alegre, Brazil
          188808 Nephron 1996;72:67–71
          © 1996 S. Karger AG, Basel

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          Pages: 5
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