Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease.

Lucas-Jiménez, Olaia; Ojeda, Natalia; Peña, Javier Jiménez; Díez-Cirarda, María; Cabrera-Zubizarreta, Alberto; Gómez-Esteban, Juan Carlos; Gómez-Beldarrain, María Ángeles; Ibarretxe-Bilbao, Naroa

doi:10.1016/j.parkreldis.2016.09.012

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Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease.

Author(s): Olaia Lucas-Jiménez ¹ , Natalia Ojeda ¹ , Javier Peña ¹ , María Díez-Cirarda ¹ , Alberto Cabrera-Zubizarreta ² , Juan Carlos Gómez-Esteban ³ , María Ángeles Gómez-Beldarrain ⁴ , Naroa Ibarretxe-Bilbao ⁵

Publication date (Electronic): Dec 2016

Journal: Parkinsonism & related disorders

Publisher: Elsevier BV

Keywords: Cognitive impairment, Default mode network, Diffusion-weighted imaging, Functional connectivity, Gray matter, Parkinson's disease

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Abstract

To assess whether functional neural connectivity is disrupted between the regions of the default mode network (DMN) in Parkinson's disease (PD) and how this connectivity is related to cognition, brain gray matter structure and white matter integrity and diffusivity.

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Journal ID (iso-abbrev): Parkinsonism Relat. Disord.

Title: Parkinsonism & related disorders

Publisher: Elsevier BV

ISSN (Electronic): 1873-5126

ISSN (Print): 1353-8020

Publication date (Electronic): Dec 2016

Volume: 33

Affiliations

[1 ] Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain.

[2 ] OSATEK, MR Unit Hospital of Galdakao, Galdakao, Usansolo, Spain.

[3 ] Neurodegenerative Diseases Group, Biocruces Health Research Institute, University of Basque Country, Barakaldo, Spain.

[4 ] Department of Neurology, Hospital of Galdakao, Galdakao, Usansolo, Spain.

[5 ] Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain. Electronic address: naroa.ibarretxe@deusto.es.

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Publisher Item ID: S1353-8020(16)30337-6

DOI: 10.1016/j.parkreldis.2016.09.012

PubMed ID: 27659747

SO-VID: 48977112-559f-483d-86a1-001de2ecdd6b

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Keywords: Cognitive impairment,Default mode network,Diffusion-weighted imaging,Functional connectivity,Gray matter,Parkinson's disease

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Keywords: Cognitive impairment, Default mode network, Diffusion-weighted imaging, Functional connectivity, Gray matter, Parkinson's disease

Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease.

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Karger: Neurology and Neuroscience

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