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Using GeneWise in the Drosophila Annotation Experiment
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Abstract
The GeneWise method for combining gene prediction and homology searches was applied
to the 2.9-Mb region from Drosophila melanogaster. The results from the Genome Annotation
Assessment Project (GASP) showed that GeneWise provided reasonably accurate gene predictions.
Further investigation indicates that many of the incorrect gene predictions from GeneWise
were due to transposons with valid protein-coding genes and the remaining cases are
pseudogenes or possible annotation oversights.