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      Mechanisms of mitophagy

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      Nature Reviews Molecular Cell Biology
      Springer Science and Business Media LLC

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          Abstract

          Autophagy not only recycles intracellular components to compensate for nutrient deprivation but also selectively eliminates organelles to regulate their number and maintain quality control. Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, mediated by autophagy-related 32 (Atg32), and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L). Moreover, mitophagy is regulated in many metazoan cell types by parkin and PTEN-induced putative kinase protein 1 (PINK1), and mutations in the genes encoding these proteins have been linked to forms of Parkinson's disease.

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          Author and article information

          Journal
          Nature Reviews Molecular Cell Biology
          Nat Rev Mol Cell Biol
          Springer Science and Business Media LLC
          1471-0072
          1471-0080
          January 2011
          December 22 2010
          January 2011
          : 12
          : 1
          : 9-14
          Article
          10.1038/nrm3028
          4780047
          21179058
          48a856e6-af4e-4889-91f6-1daf8c4779c7
          © 2011

          http://www.springer.com/tdm

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