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      Replacement Therapy in Hypothalamus-Pituitary Insufficiency: Management in the Adolescent

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          Abstract

          GH, formerly administered 2-3 times a week intramuscularly, is nowadays injected daily subcutaneously at a dosage of 14 IU/m<sup>2</sup>/day. In some patients, a 1.5- to 2.0-fold higher GH dosage is necessary for normal pubertal growth spurt. Though delayed initiation of puberty in additional gonadotropin deficiency may be favourable for final height, puberty should be induced in boys at bone age 12–13 years with low doses of testosterone enanthate, and in girls at bone age 12 years with low doses of ethinyl estradiol. Patients with additional ACTH deficiency should receive only a low-dose glucocorticoid replacement (but a steroid cover for physical stress situations). During GH therapy, thyroid function has to be evaluated regularly; often thyroxine replacement will be necessary.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5290-5
          978-3-318-01979-7
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 33
          : Suppl 4
          : 38-44
          Affiliations
          Department of Pediatrics, University Clinic Hamburg, FRG
          Article
          181582 Horm Res 1990;33:38–44
          10.1159/000181582
          2174018
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          The Seville hGH Symposium

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