Blog
About

28
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Behcet's Disease: New Concepts in Cardiovascular Involvements and Future Direction for Treatment

      * ,

      ISRN Pharmacology

      International Scholarly Research Network

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Behcet's disease (BD) is the only systemic vasculitis involving both arteries and vein in any sizes. It frequently encounters in rheumatology clinics. It has some major morbidities and even fatal outcomes in some cases. The aim of this paper is to analyze the main concepts on pathophysiology and treatment options in BD, focusing on cardiovascular aspects, thrombosis, and potential future treatment.

          Related collections

          Most cited references 185

          • Record: found
          • Abstract: found
          • Article: not found

          Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.

          Acute lung injury (ALI) causes high mortality, but its molecular mechanisms are poorly understood. Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI. Acid aspiration induced P-selectin-dependent platelet-neutrophil interactions in blood and in lung capillaries. Reducing circulating platelets or blocking P-selectin halted the development of ALI. Bone marrow chimeras showed that platelet, not endothelial, P-selectin was responsible for the injury. The interaction of platelets with neutrophils and endothelia was associated with TXA(2) formation, with detrimental effects on permeability and tissue function. Activated platelets induced endothelial expression of ICAM-1 and increased neutrophil adhesion. Inhibition of platelet-neutrophil aggregation improved gas exchange, reduced neutrophil recruitment and permeability, and prolonged survival. The key findings were confirmed in a sepsis-induced model of ALI. These findings may translate into improved clinical treatments for ALI.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Platelet activation: assessment and quantification.

             Mohan Kamath,  A Blann,  G Lip (2001)
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Mean platelet volume as an indicator of platelet activation: methodological issues.

              Mean platelet volume (MPV) is increased in patients at high risk for athero-thrombotic diseases. Thus, an elevated MPV may be a risk marker for platelet activation. Healthy subjects with normal triglyceride (TG) levels (90+/-6 mg/dl; n = 40) or mild hypertriglyceridemia (161+/-79 mg/dl; n = 32) were studied. MPV was measured in fasting blood samples before and after stimulation with collagen (10 micro g/ml), and exposure to 4 or 37 degrees C. Samples from the normotriglyceridemic subjects were tested again 4 h after consuming a high-fat drink. Collagen and exposure to 4 degrees C increased MPV, whereas incubation at 37 degrees C lowered MPV regardless of TG level. There was no significant difference in unstimulated MPV between the fasting and the fed states in the normotriglyceridemic subjects (both 7.2+/-0.1 fl; mean+/-SEM), nor between the latter group and hypertriglyceridemic subjects (7.0+/-0.1 fl). There was a significant negative relation between MPV and fasting TG level. This study suggests that MPV response to low-dose collagen may be a useful indicator of platelet propensity to activation. Further studies are warranted to correlate MPV with classical platelet aggregation tests and with the use of platelet-active drugs.
                Bookmark

                Author and article information

                Journal
                ISRN Pharmacol
                ISRN Pharmacol
                ISRN.PHARMACOLOGY
                ISRN Pharmacology
                International Scholarly Research Network
                2090-5165
                2090-5173
                2012
                8 March 2012
                : 2012
                Affiliations
                Division of Rheumatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
                Author notes

                Academic Editors: S. Ceruti and R. Fantozzi

                Article
                10.5402/2012/760484
                3317002
                22530146
                Copyright © 2012 M. B. Owlia and G. Mehrpoor.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Categories
                Review Article

                Pharmacology & Pharmaceutical medicine

                Comments

                Comment on this article