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      Quantitative evaluation of potential irradiation geometries for carbon-ion beam grid therapy.

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          Abstract

          Radiotherapy using grids containing cm-wide beam elements has been carried out sporadically for more than a century. During the past two decades, preclinical research on radiotherapy with grids containing small beam elements, 25 μm-0.7 mm wide, has been performed. Grid therapy with larger beam elements is technically easier to implement, but the normal tissue tolerance to the treatment is decreasing. In this work, a new approach in grid therapy, based on irradiations with grids containing narrow carbon-ion beam elements was evaluated dosimetrically. The aim formulated for the suggested treatment was to obtain a uniform target dose combined with well-defined grids in the irradiated normal tissue. The gain, obtained by crossfiring the carbon-ion beam grids over a simulated target volume, was quantitatively evaluated.

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          Author and article information

          Journal
          Med Phys
          Medical physics
          Wiley
          2473-4209
          0094-2405
          Mar 2018
          : 45
          : 3
          Affiliations
          [1 ] Department of Radiation Oncology, Osaka University Graduate School of Medicine, 565-0871, Osaka, Japan.
          [2 ] Medical Radiation Physics, Department of Physics, Stockholm University, S-171 76, Stockholm, Sweden.
          [3 ] Department of Oncology and Pathology, Karolinska University Hospital, S-171 76, Stockholm, Sweden.
          Article
          10.1002/mp.12749
          29319842

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