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      Autoradiographic Localization and Age-Related Changes in Vasopressin Receptors in Spontaneously Hypertensive Rats

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          Abstract

          To understand the regulation of vasopressin receptors in an animal model of hypertension, localization and age-related changes in renal arginine vasopressin (AVP) receptors in spontaneously hypertensive rats (SHR) were investigated using in vitro (macro) autoradiography and a radiolabeled receptor assay. Autoradiography localized renal AVP V2 receptors to the distal tubules and collecting ducts in the medulla. We also found small numbers of AVP-binding sites within glomeruli, possibly representing VI receptors in the mesangium. The radiolabeled receptor assay of the medulla membrane fraction revealed that the binding affinity of renal V2 receptors did not differ significantly between SHR and control Wistar-Kyoto rats in any age group. However, the binding capacity (B<sub>max</sub>) for V2 receptors in 12-week-old SHR was significantly increased (p < 0.025) as compared with that of age-matched control rats. The B<sub>max</sub> values for V2 receptors in 3- and 7-week-old SHR were not significantly different from those of age-matched controls. There was no significant change in urine volume between SHR and control rats at the age of 12 weeks. The mean plasma AVP concentration in SHR increased at 7 and 12 weeks of age. These findings suggest that SHR have different developmental changes in kidney AVP receptors and that renal V2 receptors play a role in maintaining fluid homeostasis in SHR with established hypertension.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1996
          1996
          18 December 2008
          : 72
          : 2
          : 281-287
          Affiliations
          a3rd Department of Internal Medicine, Okayama University Medical School, and bDepartment of Nursing, School of Health Sciences, Okayama University, Okayama, Japan
          Article
          188855 Nephron 1996;72:281–287
          10.1159/000188855
          8684540
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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