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      A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation

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          Abstract

          We compared the innate immune response to newly emerged swine origin H3N2 influenza A variant virus containing the M gene from A(H1N1)pdm09 virus (A(H3N2)vpm), with 2010 swine-origin A(H3N2)v and seasonal A(H3N2) viruses. Our results demonstrated that A(H3N2)vpM virus-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of pro-inflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM virus infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.

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          Author and article information

          Journal
          Journal ID (nlm-journal-id): 0413675
          Journal ID (pubmed-jr-id): 4830
          Journal ID (nlm-ta): J Infect Dis
          Journal ID (iso-abbrev): J. Infect. Dis.
          Title: The Journal of infectious diseases
          ISSN (Print): 0022-1899
          ISSN (Electronic): 1537-6613
          Publication date Nihms-submitted: 6 January 2017
          Publication date (Electronic): 11 June 2015
          Publication date (Print): 15 December 2015
          Publication date PMC-release: 17 January 2017
          Volume: 212
          Issue: 12
          Pages: 1923-1929
          Affiliations
          [1 ]Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia
          [2 ]Virology, Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia
          [3 ]Battelle Memorial Institute, Atlanta Georgia
          [4 ]Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
          Author notes
          Corresponding Author: Dr. Weiping Cao, Immunology and Pathogenesis Branch, Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA ( wcao@ 123456cdc.gov )
          Article
          Accession ID: PMC5240150 Pmcid ID: PMC5240150 Pmc-uid ID: 5240150 Manuscript ID: hhspa750995
          DOI: 10.1093/infdis/jiv330
          PMC ID: 5240150
          PubMed ID: 26068782
          SO-VID: 48c56f23-793f-4838-ba00-a5ad814fcb2e
          History
          Categories
          Subject: Article

          Keywords: pro-inflammatory cytokines,type I IFN,ROS,inflammasome activation,A(H3N2)vpM,myeloid dendritic cell
          Data availability:
          Keywords: pro-inflammatory cytokines, type I IFN, ROS, inflammasome activation, A(H3N2)vpM, myeloid dendritic cell

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