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      Prostaglandin E 2 in the Vitreous Body of the Normal Rabbit Eye and after Ocular Trauma

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          Abstract

          Rabbit eyes were enucleated and frozen in liquid nitrogen. The vitreous was removed and analyzed for prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). The mean level ( ± SEM) of PGE<sub>2</sub> in the anterior as well as in the posterior vitreous was 0.09 ± 0.016 ng/ml (n = 12 rabbits). Animals pretreated with indomethacin 15 min before death, in order to prevent the formation of prostaglandin during enucleation, showed in both the anterior and posterior vitreous mean PGE<sub>2</sub> levels of 0.04 ± 0.008 ng/ml (n = 12) which were significantly lower. Ocular trauma such as paracentesis of the anterior chamber, indentation of the sclera or laser photocoagulation in the fundus 1 h before death of the animals did not increase the concentration of PGE<sub>2</sub> in the vitreous humor. There is no evidence either for local release of PGE<sub>2</sub> from tissues in the fundus of the eye or for diffusion of PGE<sub>2</sub> from the anterior chamber into the vitreous humor.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1991
          1991
          10 December 2009
          : 23
          : 5
          : 240-245
          Affiliations
          aDepartment of Ophthalmology, Leiden Medical Center, Leiden; bThe Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
          Article
          267119 Ophthalmic Res 1991;23:240–245
          10.1159/000267119
          1784455
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Paper

          Vision sciences, Ophthalmology & Optometry, Pathology

          Prostaglandin E2 , Rabbit eye, Vitreous body

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