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      Prostaglandin E 2 in the Vitreous Body of the Normal Rabbit Eye and after Ocular Trauma

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          Rabbit eyes were enucleated and frozen in liquid nitrogen. The vitreous was removed and analyzed for prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). The mean level ( ± SEM) of PGE<sub>2</sub> in the anterior as well as in the posterior vitreous was 0.09 ± 0.016 ng/ml (n = 12 rabbits). Animals pretreated with indomethacin 15 min before death, in order to prevent the formation of prostaglandin during enucleation, showed in both the anterior and posterior vitreous mean PGE<sub>2</sub> levels of 0.04 ± 0.008 ng/ml (n = 12) which were significantly lower. Ocular trauma such as paracentesis of the anterior chamber, indentation of the sclera or laser photocoagulation in the fundus 1 h before death of the animals did not increase the concentration of PGE<sub>2</sub> in the vitreous humor. There is no evidence either for local release of PGE<sub>2</sub> from tissues in the fundus of the eye or for diffusion of PGE<sub>2</sub> from the anterior chamber into the vitreous humor.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          10 December 2009
          : 23
          : 5
          : 240-245
          aDepartment of Ophthalmology, Leiden Medical Center, Leiden; bThe Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
          267119 Ophthalmic Res 1991;23:240–245
          © 1991 S. Karger AG, Basel

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          Page count
          Pages: 6

          Vision sciences, Ophthalmology & Optometry, Pathology

          Prostaglandin E2 , Rabbit eye, Vitreous body


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