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      The Effect of Darkness and Pargyline on the Activity of Serotonin N-Acetyltransferase in the Rat Epiphysis

      Neuroendocrinology

      S. Karger AG

      Epiphysis, N-acetyltransferase, Darkness, Monoamine oxidase inhibitor

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          Abstract

          The activity of N-acetyltransferase in theepiphysis is significantly increased by 3 h of darkness after the evening switching off of the animal room lights, but not by a similar period of darkness experienced during daylight hours. However, in rats maintained in constant light, the enzyme activity increases after 3 h of darkness experienced during daylight hours. It would appear that the increase in enzyme activity is a complex function of both darkness per se and a rhythmic ability of the organism to respond to darkness. Administration of the monoamine oxidase inhibitor pargyline during the day produces first a decrease in enzyme activity and then an increase by a factor of 4 to 8. The degree of the increase is not dependent upon the time of day at which pargyline is given. Administration of pargyline in the evening causes an increase in N-acetyltransferase activity by a factor of only 2 to 3 and does not prevent the decrease in activity caused by turning the lights on at night. The administration of pargyline does not permit rats to respond to darkness during the day by increased N-acetyltransferase activity.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 16
          : 3-4
          : 202-211
          Affiliations
          Institute of Physiology, Czechoslovak Academy of Sciences, Prague
          Article
          122566 Neuroendocrinology 1974;16:202–211
          10.1159/000122566
          4449586
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Paper

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