13
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      The Effect of Darkness and Pargyline on the Activity of Serotonin N-Acetyltransferase in the Rat Epiphysis

      research-article
      Neuroendocrinology
      S. Karger AG
      Epiphysis, N-acetyltransferase, Darkness, Monoamine oxidase inhibitor

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The activity of N-acetyltransferase in theepiphysis is significantly increased by 3 h of darkness after the evening switching off of the animal room lights, but not by a similar period of darkness experienced during daylight hours. However, in rats maintained in constant light, the enzyme activity increases after 3 h of darkness experienced during daylight hours. It would appear that the increase in enzyme activity is a complex function of both darkness per se and a rhythmic ability of the organism to respond to darkness. Administration of the monoamine oxidase inhibitor pargyline during the day produces first a decrease in enzyme activity and then an increase by a factor of 4 to 8. The degree of the increase is not dependent upon the time of day at which pargyline is given. Administration of pargyline in the evening causes an increase in N-acetyltransferase activity by a factor of only 2 to 3 and does not prevent the decrease in activity caused by turning the lights on at night. The administration of pargyline does not permit rats to respond to darkness during the day by increased N-acetyltransferase activity.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 16
          : 3-4
          : 202-211
          Affiliations
          Institute of Physiology, Czechoslovak Academy of Sciences, Prague
          Article
          122566 Neuroendocrinology 1974;16:202–211
          10.1159/000122566
          4449586
          48e28342-d721-4da3-bf99-d71abb3c3452
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 16 November 1973
          : 10 June 1974
          Page count
          Pages: 10
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Epiphysis,N-acetyltransferase,Monoamine oxidase inhibitor,Darkness

          Comments

          Comment on this article