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      The metabolic syndrome

      , ,
      The Lancet
      Elsevier BV

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          Abstract

          The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.

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          Author and article information

          Journal
          The Lancet
          The Lancet
          Elsevier BV
          01406736
          April 2005
          April 2005
          : 365
          : 9468
          : 1415-1428
          Article
          10.1016/S0140-6736(05)66378-7
          15836891
          48f955a6-f5af-440d-84b7-5f9d3b22053b
          © 2005

          https://www.elsevier.com/tdm/userlicense/1.0/

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