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      Systemic Elevation of Proinflammatory Interleukin 18 in HIV/HCV Coinfection versus HIV or HCV Monoinfection.

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          Abstract

          HIV/HCV coinfection and elevated interleukin (IL)-18 levels are both associated with enhanced progression of hepatic inflammation and increased risk of diabetes, kidney disease, and cardiovascular disease. IL-18 is a proinflammatory cytokine made upon activation of the inflammasome, an innate sensing system. We assessed whether increased IL-18 could explain the increased incidence and progression of inflammatory conditions seen with HIV/HCV coinfection.

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          Author and article information

          Journal
          Clin. Infect. Dis.
          Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
          Oxford University Press (OUP)
          1537-6591
          1058-4838
          March 01 2017
          : 64
          : 5
          Affiliations
          [1 ] Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
          [2 ] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
          Article
          ciw771
          10.1093/cid/ciw771
          27927859

          HIV, HCV, coinfection, cytokines, inflammation

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