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      Effects of partial desulfation on antioxidant and inhibition of DLD cancer cell of Ulva fasciata polysaccharide.

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          Abstract

          Ulva fasciata belonging to the family Ulvaceae, commonly known as 'sea lettuce', is an abundantly growing green seaweed in coastal seashore of South China. Three different molecular weight sulfated polysaccharides (UFP1, UFP2 and UFP3) were extracted and separated from U. fasciata by hot water extraction and ultrafiltration. The three native UFP fractions had partial desulfurization by solvolytic desulfation respectively and the effect of sulfate content on the exhibition of the antioxidant and anti-tumor capacities had been evaluated and compared. The results showed that each native polysaccharide (UFP1, UFP2, UFP3) with high sulfate content exhibited better antioxidant activities compared with the partial desulfated polysaccharides (DS-UFP1, DS-UFP2, DS-UFP3). Specifically, UFP2 with relatively high sulfate content, molecular weight and uronic acid content had consistently excellent antioxidant performances. However, UFP2 demonstrated the minimal inhibitory effects on growth of DLD intestinal cancer cells. Instead, DS-UFP3 with the lowest sulfate content but highest uronic acid content and molecular weight exhibited the best antitumor activity.

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          Author and article information

          Journal
          Int J Biol Macromol
          International journal of biological macromolecules
          Elsevier BV
          1879-0003
          0141-8130
          Apr 2014
          : 65
          Affiliations
          [1 ] Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China.
          [2 ] School of Public Health, Curtin Health Innovation Research Institute, International Institute of Agri-Food Security, Curtin University, GPO Box U1987, Perth, WA 6845, Australia.
          [3 ] Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China. Electronic address: sunpl1964@163.com.
          Article
          S0141-8130(14)00044-0
          10.1016/j.ijbiomac.2014.01.043
          24463264
          48fe46db-3e7f-42d4-a05a-9b313f7efdd6
          Copyright © 2014 Elsevier B.V. All rights reserved.
          History

          Activity,Partial desulfation,Ulva fasciata polysaccharides

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