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      Organization and Running of the First Comprehensive Hereditary Cancer Clinic in India

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          Abstract

          Hereditary cancers are thought to account for around 5% of cancers, particularly breast/ovarian and colorectal cancers. In India there is a paucity of data on hereditary cancers and the mutations in some of the common genes linked to hereditary cancers, such as BRCA1, BRCA2, hMSH2 and hMLH1. The country's first comprehensive hereditary cancer clinic was established in February 2002. The article describes the organization and running of the Clinic. It also discusses some of the social issues relevant to the given population in running the Hereditary Cancer Clinic.

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          • Record: found
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          A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines.

          M A Rodriguez-Bigas, C R Boland, S Hamilton … (1997)
          Article 0 comments Cited 164 times – based on 0 reviews     Review now
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            Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

            F P Li, J F Fraumeni (1969)
            Article 0 comments Cited 138 times – based on 0 reviews     Review now
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              Germline mutations in the TP53 gene.

              R Eeles (1994)
              Since the majority of germline mutations in the TP53 gene seem to occur in LFS or LFL families, and these are rare, research is best conducted in a collaborative setting (Li and Fraumeni, in press). In a report from a meeting at Bethesda in 1993, the following areas were outlined for collaborative study: the correlation (if any) of phenotypes with specific mutation; age specific penetrance; cumulative cancer incidence; gender differences in tumour development in carriers; the effects of DNA damaging agents on individuals with a TP53 mutation; the frequency of TP53 germline mutations in cohorts of patients with rare childhood tumours (eg adrenocortical carcinoma); and the psychosocial aspects of predictive TP53 testing. In addition, if, as seems likely from recent data, X irradiation in these individuals induces DNA damage that is tolerated, urgent collaborative studies are needed to investigate new methods of screening, such as magnetic resonance imaging. Treatment modalities should be carefully chosen, and for this reason alone, predictive testing may be desirable in all LFS and LFL families. Individuals carrying TP53 mutations could be offered chemoprevention within trials in an effort to reduce their mortality from cancer.
              Article 0 comments Cited 34 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Hered Cancer Clin Pract
                Title: Hereditary Cancer in Clinical Practice
                Publisher: BioMed Central
                ISSN (Print): 1731-2302
                ISSN (Electronic): 1897-4287
                Publication date Collection: 2005
                Publication date (Electronic): 15 November 2005
                Volume: 3
                Issue: 4
                Pages: 165-170
                Affiliations
                [1 ]Dept. of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai - 600020, India
                [2 ]Dept. of Preventive Oncology, Cancer Institute (WIA), Adyar, Chennai - 600020, India
                [3 ]Dept. of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai - 600020, India
                [4 ]Dept. of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai - 600020, India
                [5 ]Dept. of Radiation Oncology, Cancer Institute (WIA), Adyar, Chennai - 600020, India
                Article
                Publisher ID: 1897-4287-3-4-165
                DOI: 10.1186/1897-4287-3-4-165
                PMC ID: 2837059
                PubMed ID: 20223043
                SO-VID: 4912158a-1f20-4977-8434-a6a995600f10
                History
                Date received : 28 October 2005
                Date accepted : 1 November 2005
                Categories
                Subject: Research

                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: hereditary cancer clinic,mutation analysis,india,dhplc,hereditary cancers,social issues
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: hereditary cancer clinic, mutation analysis, india, dhplc, hereditary cancers, social issues

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