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      The posterior approach operation to treat thoracolumbar disc herniation : A minimal 2-year follow-up study

      research-article
      , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD
      Medicine
      Wolters Kluwer Health
      posterior approach, thoracolumbar disc herniation, TLDH

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          Abstract

          Thoracolumbar disc herniation (TLDH) is a rare and progressively disabling disorder; surgical procedures predispose the subjects to high incidence of complications including recurrence, neurological aggravation, and adjacent segment degeneration.

          Ten patients with TLDH underwent posterior approach operation in our institution from January, 2006 to December, 2015. The mean preoperative duration of clinical symptoms was 16.5 months. The clinical data including operative time, blood loss, and hospitalization duration were investigated. Furthermore, pre and postoperative neurological status was evaluated by the modified Japanese Orthopedic Association (JOA) scoring system and pain by visual analog scale (VAS) scoring system.

          The mean operative time was 176.50 ± 20.55 minutes, the mean blood loss was 435.00 ± 89.58 mL, and the mean hospitalization length was 13.30 ± 2.97 days. All patients were followed with a mean period of 35.1 months. The mean JOA score of all patients before operation, at discharge, 3 months after operation, and at last follow-up was 6.50 ± 1.28, 7.60 ± 1.22, 8.90 ± 0.99, and 9.00 ± 0.92, respectively. The differences between the pre and postoperative JOA and VAS scores were significant ( P < .05). However, the differences of JOA and VAS scores at postoperative 3 months and final follow-up were not statistically significant.

          Posterior approach operation is an ideal surgical technique for treatment of TLDH; the operative time, blood loss, hospitalization duration, and symptomatic improvement are favorable.

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          Most cited references23

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          Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model.

          Methylcobalamin is a vitamin B12 analog and is necessary for the maintenance of the nervous system. Although some previous studies have referred to the effects of methylcobalamin on neurons, the precise mechanism of this effect remains obscure. Here we show that methylcobalamin at concentrations above 100 nM promotes neurite outgrowth and neuronal survival and that these effects are mediated by the methylation cycle, a metabolic pathway involving methylation reactions. We also demonstrate that methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle. In a rat sciatic nerve injury model, continuous administration of high doses of methylcobalamin improves nerve regeneration and functional recovery. Therefore, methylcobalamin may provide the basis for better treatments of nervous disorders through effective systemic or local delivery of high doses of methylcobalamin to target organs. Copyright 2009 Elsevier Inc. All rights reserved.
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            The unique characteristics of "upper" lumbar disc herniations.

            To compare the characteristics, presentation, and surgical outcome of patients with microdiscectomies at L1-L2 and L2-L3 with those we treated at L3-L4. We further sought to compare these results with those reported in the literature for discectomies at the L4-L5 and L5-S1 levels. We reviewed the clinical data collected from 69 patients who had 72 L1-L2, L2-L3, and L3-L4 microdiscectomies performed from 1989 to 1999 at the New York University Medical Center. Patients who had surgery at L1-L2 or L2-L3 were grouped and compared with those treated at the L3-L4 level. Patients' charts were retrospectively reviewed at a mean of 12.9 months after surgery for presenting signs and symptoms, patient characteristics, and surgical outcome. Long-term follow-up via telephone interview was obtained at an average of 81.3 months after surgery. In the L1-L2 + L2-L3 group, 58% of the patients had previous lumbar disc surgery, compared with only 10% of those in the L3-L4 group, and 20% in the L1-L2 + L2-L3 group required a fusion during the procedure compared with only 10% in the L3-L4 group. These differences are both statistically significant. The short-term chart review demonstrates that only 58% and 53% of patients in the L1-L2 + L2-L3 group were improved with regard to radicular and back pain, respectively, whereas those in the L3-L4 group reported 94 and 87% rates of improvement in the same categories, both highly statistically significant findings. The long-term follow-up confirmed a highly statistically significantly worse outcome in the L1-L2 + L2-L3 group, with only 33% of patients reporting an improvement in their economic or functional status, compared with an 88% rate of improvement in the L3-L4 group. The outcome of our patients with L3-L4 herniations was similar to that reported in the literature for herniations at L4-L5 and L5-S1. Herniated discs at the L1-L2 or L2-L3 level are different entities from those at lower levels of the lumbar spine. The surgical outcome in terms of postoperative back and radicular pain is worse for herniated discs at L1-L2 and L2-L3 compared with those treated at L3-L4. Our patients with L1-L2 or L2-L3 surgically treated herniated discs were more likely to have had previous lumbar surgery and required a fusion more often than their counterparts with L3-L4 herniated discs.
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              Early disability risk factors for low back pain assessed at outpatient occupational health clinics.

              Inception cohort (
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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Wolters Kluwer Health
                0025-7974
                1536-5964
                April 2018
                20 April 2018
                : 97
                : 16
                : e0458
                Affiliations
                Department of Orthopaedics, General Hospital of Jinan Military Region, People's Liberation Army, Jinan, Shandong Province, China.
                Author notes
                []Correspondence: Xiuchun Yu, Department of Orthopaedics, General Hospital of Jinan Military Region, People's Liberation Army, 25 Shifan Road, Jinan, Shandong Province 250031, China (e-mails: 13969132190@ 123456163.com , startdmxx@ 123456hotmail.com ).
                Article
                MD-D-17-03625 00458
                10.1097/MD.0000000000010458
                5916692
                29668617
                49274f43-4e8c-4f98-9426-fc9603e75a5f
                Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0

                History
                : 10 June 2017
                : 11 March 2018
                : 22 March 2018
                Categories
                3700
                Research Article
                Observational Study
                Custom metadata
                TRUE

                posterior approach,thoracolumbar disc herniation,tldh

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