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      Physiology of Mechanotransduction: How Do Muscle and Bone "Talk" to One Another?

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          Abstract

          The complexity of cell interactions with their microenvironment and their ability to communicate at the autocrine, paracrine, and endocrine levels has gradually but significantly evolved in the last three decades. The musculoskeletal system has been historically recognized to be governed by a relationship of proximity and function, chiefly dictated by mechanical forces and the work of gravity itself. In this review article, we first provide a historical overview of the biomechanical theory of bone- muscle interactions. Next, we expand to detail the significant evolution in our understanding of the function of bones and muscles as secretory organs. Then, we review and discuss new evidence in support of a biochemical interaction between these two tissues. We then propose that these two models of interaction are complementary and intertwined providing for a new frontier for the investigation of how bone-muscle cross talk could be fully explored for the targeting of new therapies for musculoskeletal diseases, particularly the twin conditions of aging, osteoporosis and sarcopenia. In the last section, we explore the bone-muscle cross talk in the context of their interactions with other tissues and the global impact of these multi-tissue interactions on chronic diseases.

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          Author and article information

          Journal
          Clin Rev Bone Miner Metab
          Clinical reviews in bone and mineral metabolism
          1534-8644
          1534-8644
          Jun 2014
          : 12
          : 2
          Affiliations
          [1 ] Muscle Biology Research Group-MUBIG, School of Nursing and Health Studies, University of Missouri-Kansas City (UMKC), 2464 Charlotte St, Kansas City, MO 64108, USA; Nursing Program, Johnson County Community College, Overland Park, KS 66210, USA.
          [2 ] Muscle Biology Research Group-MUBIG, School of Nursing and Health Studies, University of Missouri-Kansas City (UMKC), 2464 Charlotte St, Kansas City, MO 64108, USA; School of Medicine, UMKC, Kansas City, MO, USA; School of Pharmacy, UMKC, Kansas City, MO, USA.
          Article
          NIHMS672468
          10.1007/s12018-013-9152-3
          25838800
          49282743-a82e-4605-b5df-6bf613546ae2
          History

          Bones,Bone–muscle cross talk,Cross talk,Mechanostat,Muscles,Musculoskeletal,Myokines,Osteoporosis,Sarcopenia

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