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      Understanding inherited genetic risk of adult glioma – a review

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          Abstract

          During the past six years, researchers have made major progress identifying common inherited genetic variation that increases risk for primary adult glioma. This paper summarizes knowledge about rare familial cancer syndromes that include adult glioma and reviews the available literature on the more recently discovered common inherited variation. Ten independent inherited variants in eight chromosomal regions have been convincingly associated with increased risk for adult glioma. Most of these variants increase relative risk of primary adult glioma by 20% to 40%, but the TP53 variant rs78378222 confers a two-fold relative risk (ie, 200%), and rs557505857 on chromosome 8 confers a six-fold relative risk of IDH-mutated astrocytomas and oligodendroglial tumors (ie, 600%). Even with a six-fold relative risk, the overall risk of developing adult glioma is too low for screening for the high-risk variant on chromosome 8. Future studies will help clarify which inherited adult glioma risk variants are associated with subtypes defined by histology and/or acquired tumor mutations. This review also provides an information sheet for primary adult glioma patients and their families.

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          Author and article information

          Journal
          Neurooncol Pract
          Neurooncol Pract
          nop
          nop
          Neuro-Oncology Practice
          Oxford University Press
          2054-2577
          2054-2585
          March 2016
          25 August 2015
          1 March 2017
          : 3
          : 1
          : 10-16
          Affiliations
          Division of Neuroepidemiology, Department of Neurological Surgery, University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.); Department of Epidemiology and Biostatistics, University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.)
          Author notes
          Corresponding Author: Terri Rice, MPH, University of California, San Francisco ( terri.rice@ 123456ucsf.edu ).
          [†]

          Co-senior authors.

          Article
          PMC4774334 PMC4774334 4774334 npv026
          10.1093/nop/npv026
          4774334
          26941959
          493267ae-8265-4612-b417-78b56c248d4d
          © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
          History
          : 20 March 2015
          Funding
          Funded by: National Institutes of Health http://dx.doi.org/10.13039/100000002
          Award ID: R01CA52689, P50CA097257, R01CA126831, R01CA139020, R25CA112355 and R01CA163687
          Award ID: P50CA108961, P30 CA15083, RC1NS068222Z
          Funded by: National Brain Tumor Foundation; Sence Foundation
          Funded by: Brain Tumor Research; Robert Magnin Newman Endowed Chair in Neuro-oncology
          Funded by: Bernie and Edith Waterman Foundation
          Funded by: Ting Tsung and Wei Fong Chao Family Foundation
          Funded by: National Center for Research Resources and the National Center for Advancing Translational Sciences
          Funded by: National Institutes of Health http://dx.doi.org/10.13039/100000002
          Award ID: NuUL1 RR024131
          Funded by: California Department of Public Health http://dx.doi.org/10.13039/100005002
          Award ID: 103885
          Funded by: National Cancer Institute's Surveillance, Epidemiology and End Results Program
          Award ID: HHSN261201000140C
          Funded by: Cancer Prevention Institute of California
          Award ID: HHSN261201000035C
          Funded by: University of Southern California http://dx.doi.org/10.13039/100006034
          Award ID: HHSN261201000034C
          Funded by: Disease Control and Prevention's National Program of Cancer Registries
          Award ID: # U58DP003862-01
          Funded by: California Department of Public Health http://dx.doi.org/10.13039/100005002
          Funded by: Centers for Disease Control and Prevention http://dx.doi.org/10.13039/100000030
          Award ID: 5U58DP00381-04
          Funded by: Sontag Foundation http://dx.doi.org/10.13039/100006064
          Funded by: Pediatric Brain Tumor Foundation http://dx.doi.org/10.13039/100001794
          Funded by: Musella Foundation
          Categories
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          epidemiology,genetics,primary adult glioma,risk,variants
          epidemiology, genetics, primary adult glioma, risk, variants

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