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      Uptake of 14C-Angiotensin by Canine Cutaneous Blood Vessels

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          Abstract

          The uptake of <sup>14</sup>C-angiotensin was studied in canine cutaneous blood vessels in vitro. T/M ratios of <sup>14</sup>C were 0.4, 0.5, 0.8 and 1.5 after 7.5, 15, 30 and 60 min of incubation, respectively. The T/M of <sup>14</sup>C-sorbitol, an extracellular marker, was 0.4. No difference in the T/M ratios of C<sup>14</sup> was found between normal and chronically denervated vessels incubated with <sup>14</sup>C-angiotensin; however, the uptake of <sup>3</sup>H-norepinephrine was markedly decreased in the denervated preparation. The <sup>14</sup>C taken up by the vessels after 30 min of incubation appeared to comprise both intact angiotensin and metabolites. These results suggest that a small quantity of intact angiotensin may be bound by vascular tissue, but is not concentrated in adrenergic nerve endings.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1975
          1975
          18 September 2008
          : 12
          : 2
          : 81-88
          Affiliations
          Departments of Anesthesiology and Pharmacology, University of Minnesota, Minneapolis, Minn.
          Article
          158040 Blood Vessels 1975;12:81–88
          10.1159/000158040
          © 1975 S. Karger AG, Basel

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          Pages: 8
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