The uptake of <sup>14</sup>C-angiotensin was studied in canine cutaneous blood vessels in vitro. T/M ratios of <sup>14</sup>C were 0.4, 0.5, 0.8 and 1.5 after 7.5, 15, 30 and 60 min of incubation, respectively. The T/M of <sup>14</sup>C-sorbitol, an extracellular marker, was 0.4. No difference in the T/M ratios of C<sup>14</sup> was found between normal and chronically denervated vessels incubated with <sup>14</sup>C-angiotensin; however, the uptake of <sup>3</sup>H-norepinephrine was markedly decreased in the denervated preparation. The <sup>14</sup>C taken up by the vessels after 30 min of incubation appeared to comprise both intact angiotensin and metabolites. These results suggest that a small quantity of intact angiotensin may be bound by vascular tissue, but is not concentrated in adrenergic nerve endings.