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      Characterization of a novel complex BRAF mutation in a follicular variant papillary thyroid carcinoma.

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          Abstract

          Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent BRAF mutations seem to be associated with other PTC histotypes.

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          Author and article information

          Journal
          Eur. J. Endocrinol.
          European journal of endocrinology
          Bioscientifica
          1479-683X
          0804-4643
          Jul 2008
          : 159
          : 1
          Affiliations
          [1 ] Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, I-35121 Padova, Italy.
          Article
          EJE-08-0239
          10.1530/EJE-08-0239
          18426810
          494db5cf-0612-4b93-9d61-02bee65c31f9
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