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      Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy.

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          Abstract

          Calcinosis cutis is a chronic calcium-mediated disease that causes significant morbidity. Multiple treatments have been tried, with varying results; indeed, to date, no standard treatment has been generally accepted. Sodium metabisulfite is an inorganic compound that, when it reacts with oxygen, becomes sodium sulfate, a metabolite of sodium thiosulfate that has a similar ability to inhibit calcium oxalate agglomeration. Four women diagnosed with calcinosis cutis, secondary to dermatomyositis, systemic sclerosis and radiodermatitis after breast cancer, were evaluated for their response to topical 25% sodium metabisulfite. In all patients a decrease in lesion size, erythema and pain from injuries was shown, with complete resolution of the associated ulcers. One patient had a complete response. None experienced adverse effects. Topical sodium metabisulfite is a promising emerging therapy that should be considered as a valid alternative treatment in calcinosis cutis. Randomized prospective studies are required to evaluate its true efficacy.

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          Author and article information

          Journal
          Br. J. Dermatol.
          The British journal of dermatology
          Wiley
          1365-2133
          0007-0963
          Sep 2016
          : 175
          : 3
          Affiliations
          [1 ] Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
          [2 ] Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
          [3 ] Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. cvera@med.puc.cl.
          Article
          10.1111/bjd.14412
          26799451

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