Blog
About

538
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Untangling the ErbB signalling network.

      Nature reviews. Molecular cell biology

      Signal Transduction, metabolism, Receptor, ErbB-2, therapy, pathology, genetics, Neoplasms, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over 25,000 women with breast cancer have now been treated with trastuzumab (Herceptin), a recombinant antibody designed to block the receptor ErbB2. Likewise, small-molecule enzyme inhibitors and monoclonal antibodies to ErbB1 are in advanced phases of clinical testing. What can this pathway teach us about translating basic science into clinical use?

          Related collections

          Author and article information

          Journal
          11252954
          10.1038/35052073

          Chemistry

          Signal Transduction, metabolism, Receptor, ErbB-2, therapy, pathology, genetics, Neoplasms, Animals

          Comments

          Comment on this article